- DRC stands for Democratic Republic of Congo
- DRC stands for Director(ate) of Reserve Components
- DRC stands for Down (Stage) Right Center
- DRC stands for Disability Resource Center
- DRC stands for Direction des Relations avec les Collectivités (French: Directorate of Community Relations)
- DRC stands for Disability Rights Commission (United Kingdom)
- DRC stands for Domaine de la Romanée Conti (French winery; Burgundy, France)
- DRC stands for Department of Rehabilitation and Correction (Ohio, USA)
- DRC stands for Disaster Recovery Center
- DRC stands for Dynamics Research Corporation
- DRC stands for Digital Resource Commons (Ohio)
- DRC stands for Development Review Committee
- DRC stands for Danish Refugee Council
- DRC stands for Development Resource Center (various locations)