- DMC stands for Detroit Medical Center
- DMC stands for Destination Management Company
- DMC stands for Data Management Center (University of Washington)
- DMC stands for Devil May Cry (video game)
- DMC stands for Direct Marketing Company
- DMC stands for Del Mar College (Corpus Christi, TX)
- DMC stands for Daniels Manufacturing Corporation (Orlando, FL)
- DMC stands for Driving Me Crazy
- DMC stands for Disproportionate Minority Contact
- DMC stands for Data Monitoring Committee
- DMC stands for Ducati Monster Club (motorcycle club)
- DMC stands for Detroit Metal City (manga series)
- DMC stands for Delorean Motor Company
- DMC stands for Darryl McDaniels (rapper)
- DMC stands for Digital Multi Coated (camera filter)
- DMC stands for Division of Medicinal Chemistry (various organizations)