- DISC stands for Discover (credit card)
- DISC stands for Discount
- DISC stands for Domestic International Sales Corporation
- DISC stands for Discovery Channel (TV)
- DISC stands for Distributed Computing (International Symposium)
- DISC stands for Disconnect
- DISC stands for Discontinue
- DISC stands for Death-Inducing Signaling Complex (cell apoptosis)
- DISC stands for Dickinson Independent School District (Dickinson, TX)
- DISC stands for Distinguished Instructor Short Course (Society of Exploration Geophysicists)
- DISC stands for Disarmament and International Security Committee (various organizations)
- DISC stands for Dominance/Influence/Steadiness/Conscientiousness (personality profile)
- DISC stands for Defense Industrial Supply Center
- DISC stands for Disconnect Command
- DISC stands for Differential Scattering
- DISC stands for Dynamic Information Systems Corporation
- DISC stands for Daingerfield Island Sailing Club (Alexandria, VA)
- DISC stands for DNA Information and Stock Center
- DISC stands for Defense Information System Council
- DISC stands for Digital Information Services Center (Netherlands)
- DISC stands for Discover Information Security Compliance (Discover’s payment card industry data security standard compliance program)
- DISC stands for Disaster Information Systems Clearinghouse
- DISC stands for Data and Information Service for CliC
- DISC stands for DISA Information Systems Center
- DISC stands for Digital Info Security Company (Colorado)
- DISC stands for Direct-Injection Stratified Charge engine
DISC