- AFC stands for American Football Conference
- AFC stands for Asian Football Confederation
- AFC stands for Anti-Friction Coating (various companies)
- AFC stands for Association Football Club
- AFC stands for Australian Film Commission
- AFC stands for Adult Foster Care
- AFC stands for American Folklife Center (Library of Congress)
- AFC stands for Available for Construction (budget; various locations)
- AFC stands for Auto Finance Company
- AFC stands for Automatic Frequency Control
- AFC stands for Adelaide Football Club
- AFC stands for Associations Familiales Catholiques (French: Catholic Family Associations)
- AFC stands for Arteria Femoralis Communis (Latin: Common Femoral Artery)
- AFC stands for Assistant Fire Chief
- AFC stands for Anna Freud Centre (child psychoanalysis research; UK)
- AFC stands for Athletic Football Club
- AFC stands for Arsenal Football Club
- AFC stands for Angelika Film Center (various locations)
- AFC stands for Amateur Football Combination (league; London, England, UK)
- AFC stands for Agenda for Change (NHS pay scheme)