- XCF stands for eXperimental Computing Facility (graphics software for Irix SGI; file extension)
- XCF stands for Cross-System Coupling Facility
- XCF stands for Xinjiang Conservation Fund (China; est. 2001)
- XCF stands for Xenos Christian Fellowship
- XCF stands for X-Ray Crystallography Facility
- XCF stands for Xenomorphic Cell Foci (immunology)